Kaposi sarcoma–associated herpesvirus/human herpesvirus 8–associated lymphoproliferative disorders
نویسندگان
چکیده
منابع مشابه
Kaposi sarcoma-associated herpesvirus infects monotypic (IgM lambda) but polyclonal naive B cells in Castleman disease and associated lymphoproliferative disorders.
In a previous study, it was shown that the Kaposi sarcoma-associated herpesvirus (KSHV) was specifically associated with monotypic (IgMlambda) plasmablasts in multicentric Castleman disease (MCD). The plasmablasts occur as isolated cells in the mantle zone of B-cell follicles but may form microlymphoma or frank plasmablastic lymphoma. To determine the clonality and cellular origin of the monoty...
متن کاملKaposi Sarcoma-Associated Herpesvirus
Kaposi sarcoma-associated herpesvirus (KSHV) is known to be a human carcinogen based on sufficient evidence from studies in humans. This conclusion is based on evidence from epidemiological and molecular studies, which show that KSHV causes Kaposi sarcoma, primary effusion lymphoma, and a plasmablastic variant of multicentric Castleman disease, and on supporting mechanistic data. KSHV causes ca...
متن کاملKaposi Sarcoma Herpesvirus
First detected by Chang et al. (1994) in Kaposi sarcomas associated with the acquired immune deficiency syndrome (AIDS) (see IARC, 1996) by representational difference analysis, this virus was termed Kaposi-sarcoma-associated herpesvirus, KSHV. KSHV is also associated with primary effusion lymphoma and some cases of multicentric Castleman disease (see Section 2). In keeping with the systematic ...
متن کاملKaposi Sarcoma Herpesvirus
First detected by Chang et al. (1994) in Kaposi sarcomas associated with the acquired immune deficiency syndrome (AIDS) (see IARC, 1996) by representational difference analysis, this virus was termed Kaposi-sarcoma-associated herpesvirus, KSHV. KSHV is also associated with primary effusion lymphoma and some cases of multicentric Castleman disease (see Section 2). In keeping with the systematic ...
متن کاملKaposi sarcoma herpesvirus pathogenesis
Kaposi sarcoma herpesvirus (KSHV), taxonomical name human gammaherpesvirus 8, is a phylogenetically old human virus that co-evolved with human populations, but is now only common (seroprevalence greater than 10%) in sub-Saharan Africa, around the Mediterranean Sea, parts of South America and in a few ethnic communities. KSHV causes three human malignancies, Kaposi sarcoma, primary effusion lymp...
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ژورنال
عنوان ژورنال: Blood
سال: 2019
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2018-11-852442